Engineered
biological vesicles
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Training the Immune System to Fight Cancer
We are building a faster, more efficient way to develop Individualized Immunotherapies that target each patient’s tumor.
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Cancer is not one disease
Each person is different, each tumor is different, heterogeneous, and constantly evolving.
0M+
0M+
people are currently
living with cancer.
people are currently living with cancer.
0M+
0M+
people will die from
cancer this year.
people will die from cancer this year.
#0
#0
cause of death
worldwide.
cause of death worldwide.
The next frontier
Training the immune system to prevent cancer from coming back.
Our Solution
One delivery platform.
Multiple cancer vaccine opportunities.
One delivery platform.
Multiple cancer vaccine
opportunities.
One delivery platform.
Multiple cancer vaccine opportunities.
Loaded with the
patient's own tumorCaptures the
full tumor identityNo sequencing
requiredDelivery to the right place
in the right cells
Engineered
biological vesicles
Loaded with the patient's own tumor
Captures the
full tumor identity
No sequencing
required
Delivery
to the right place in the right cells
OncoSpheres™
A new class of individualized cancer vaccines.
Speed
9x faster manufacturing.
1
2
3
Speed
9x faster manufacturing.
1
2
3
Speed
9x faster manufacturing.
1
2
3
Compared to current mRNA cancer vaccines.
Compared to current mRNA cancer vaccines.
Individualized
immunotherapy platform
Individualized immunotherapy platform
Individualized immunotherapy platform
We harness the power of the patient’s own tumor. OncoSpheres™ capture the full antigenic profile and deliver into immune cells, training the immune system to recognize and destroy cancer.
No sequencing. Full tumor information. Manufactured in less than 7 days.
We harness the power of the patient’s own tumor. OncoSpheres™ capture the full antigenic profile and deliver into immune cells, training the immune system to recognize and destroy cancer.
No sequencing. Full tumor information. Manufactured in less than 7 days.
Hover to see more
Durable, broad protection
for patients with the toughest cancers.
for patients with the toughest cancers.
Click to see more
Click to see more
How It Works
Mechanism of Action
From tumor to immune activation, in one integrated system.
Step 1
Tumor Extraction
Tumor tissue is collected during surgery and processed.
Step 2
Vesicle Engineering (SP1)
We engineer biological vesicles for optimal intracellular delivery.
Step 3
Antigen Loading
Vesicles are loaded with the full spectrum of tumor signals through a proprietary method.
Step 4
Uptake by APCs
OncoSpheres™ are naturally taken up by antigen-presenting cells.
Step 5
Cytosolic Delivery
Vesicles fuse and release antigens directly into the cytosol.
Step 6
CD8+ T Cell Activation
Full antigen presentation activates CD8+ T cells to kill cancer cells.
Step 1
Tumor Extraction
Tumor tissue is collected during surgery and processed.
Step 2
Vesicle Engineering (SP1)
We engineer biological vesicles for optimal intracellular delivery.
Step 3
Antigen Loading
Vesicles are loaded with the full spectrum of tumor signals through a proprietary method.
Step 4
Uptake by APCs
OncoSpheres™ are naturally taken up by antigen-presenting cells.
Step 5
Cytosolic Delivery
Vesicles fuse and release antigens directly into the cytosol.
Step 6
CD8+ T Cell Activation
Full antigen presentation activates CD8+ T cells to kill cancer cells.
Step 1
Tumor Extraction
Tumor tissue is collected during surgery and processed.
Step 2
Vesicle Engineering (SP1)
We engineer biological vesicles for optimal intracellular delivery.
Step 3
Antigen Loading
Vesicles are loaded with the tumor signals through our proprietary method.
Step 4
Uptake by APCs
OncoSpheres™ are naturally taken up by antigen-presenting cells.
Step 5
Cytosolic Delivery
Vesicles fuse and release antigens directly into the cytosol.
Step 6
CD8+ T Cell Activation
Full antigen presentation activates CD8+ T cells to kill cancer cells.
Mission & Vision
Revolutionizing
the fight against cancer through
individualized medicine
Revolutionizing
the fight against cancer through individualized medicine
At SphereBio, we develop more effective and less toxic therapies by delivering therapeutic cargo directly into cells and training the immune system to fight cancer. We leverage biotechnology, synthetic virology, and AI to address diseases that have long been underserved.
We envision a world where every patient receives treatment as unique as their disease, built on precision, science, and care.
Our Story
We founded SphereBio
to develop more powerful
immunological therapies for cancer and beyond.
We founded SphereBio
to develop more powerful
immunological therapies for cancer and beyond.
We founded SphereBio
to develop more powerful immunological
therapies for cancer and beyond.
SphereBio began in a company builder program, when Julieta Porta, the company’s COO, met molecular biologist Dr. Guido Molina, who was working on vaccines designed to drive cellular immune responses. Soon after, physician and bioinformatician Dr. Martin Guerrero joined through a mutual connection, finding new ways to apply the technology specifically to cancer.
World-class team
Traction
Validated across Science,
Manufacturing & Partnerships
Real progress. Real partnerships. Real-world validation.
Real progress. Real partnerships. Real-world validation.
Proof of Concept
We activated tumor-killing immune cells with 300x more potency than conventional approaches.
Achieved
Industrial Manufacturing (SUM™)
30,000 nanoparticles per cell per day. Proprietary and patented method that works identically in lab and at pharma scale.
Achieved
PCT Patent Filed
International PCT application filed — protection in 150+ countries. Covers SUM™ method and therapeutic use of OncoSpheres™.
Filed
AWS AI Partnership
Exclusive partnership for molecular design and modeling with 90% reduction in processing time.
Active
Presented at ASCO
Featured at ASCO — the world’s leading oncology conference.
Done
Proof of Concept
We activated tumor-killing immune cells with 300x more potency than conventional approaches.
Achieved
Industrial Manufacturing (SUM™)
PCT Patent Filed
AWS AI Partnership
Presented at ASCO
Proof of Concept
We activated tumor-killing immune cells with 300x more potency than conventional approaches.
Achieved
Industrial Manufacturing (SUM™)
30,000 nanoparticles per cell per day. Proprietary and patented method that works identically in lab and at pharma scale.
Achieved
PCT Patent Filed
International PCT application filed — protection in 150+ countries. Covers SUM™ method and therapeutic use of OncoSpheres™.
Filed
AWS AI Partnership
Exclusive partnership for molecular design and modeling with 90% reduction in processing time.
Active
Presented at ASCO
Featured at ASCO — the world’s leading oncology conference.
Done
Supported by World-Class Programs
Supported by World-Class Programs
Backed by leading entrepreneurs, physicians, and industry experts.
Press releases
Contact us
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